Having determined that Lef/Tcf-dependent transcription was stimulated by insulin and IGF-1 in this cell line, we sought to define the signalling pathways used by insulin and IGF-1 to activate Lef ...

Interactions between β-catenin and LEF ... 1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of β-catenin and transcriptional activation. The wnt signal transduction ...