In the central nervous system, ApoE is mainly produced by astrocytes and transports cholesterol to neurons via ApoE receptors, which are members of the LDLR gene family. ApoE is the principal ...

Study deciphers the molecular handshake between LDL receptors and apoB100, shedding light on cholesterol metabolism and its role in cardiovascular disease. Study: Structure of apolipoprotein B100 ...

New research reveals a genetic quirk in a small species of songbird in addition to its ability to carry a tune. It turns out the zebra finch is a surprisingly healthy bird. A study published today ...

Nov. 09, 2021 (GLOBE NEWSWIRE) -- Verve Therapeutics, a biotech company pioneering a new approach to the care of cardiovascular disease with single-course gene editing medicines, today announced ...

Verve created an NHP model of HoFH by editing the LDLR gene and eliminating its expression in the livers of NHPs, leveraging Cas9 and a dual guide RNA (gRNA) strategy encapsulated in standard LNPs ...