The TCR signals via cytoplasmic tyrosine ... ZAP-70 and CD8 chimeras associated physically and kinase activity was potentiated when Lck and ZAP-70 were expressed together 36.

the CD3 chains are associated with the TCR. Blue: Intracellular receptor phosphorylation: various kinases, such as lymphocyte-specific protein tyrosine kinase (LCK), CSK, and ZAP-70, and phosphatases, ...

As a consequence, phosphorylation of TCR proximal signaling molecules, including Lck and ZAP-70, is impaired (Panel A). Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the ...

A research team behind a new study at the Hebrew University of Jerusalem has made an important breakthrough in understanding how immune cells known as T cells are activated. By using an innovative ...