Although other researchers had obtained structures of portions of the large LRRK2 protein, the structure determined by Sun and his colleagues is the first high-resolution structure of the full ...

Parkinson's disease-related protein LRRK2 structure solved using a trailblazing new technique, revealing its surprising organization in cells, and paving the way for a treatment SAN DIEGO ...

Microtubules in cells transiently interact with LRRK2 in a kinase-independent manner. While microtubule depolymerization ...

Zenobia retains all rights and ownership of the LRRK2 structure and to their internal LRRK2 chemistry program. Zenobia provides a commercial fragment library, and access to their structural ...

The top contributor to familial Parkinson's disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted ...