“In that first paper, we got the structure of LRRK2, but that structure showed an inactive conformation,” Sun explained. Proteins often have active and inactive forms, regulated by different ...

Microtubules in cells transiently interact with LRRK2 in a kinase-independent manner. While microtubule depolymerization ...

“In that first paper, we got the structure of LRRK2, but that structure showed an inactive conformation,” Sun explained. Proteins often have active and inactive forms, regulated by different cellular ...

More information: Chen, C. et al, LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons, Molecular Psychiatry (2025). DOI: 10.1038/s41380-025-03030-z Provided ...

The team's work sheds light on the pivotal role of Lrrk2, a major risk gene for Parkinson's disease, in modulating macrophage functions and immune responses. Parkinson's disease (PD) is a ...

About LRRK2 LRRK2 is a complex, multidomain protein found in neurons and many other cell types and tissues throughout the body. Mutations in the LRRK2 gene are among the most common genetic causes ...

The NEULARK trial represents a significant advancement in precision medicine, utilizing a state-of-the-art digital biomarker and patient stratification approach to identify individuals with LRRK2 ...

NEW HAVEN, Conn., June 21, 2024 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today ...

"In that first paper, we got the structure of LRRK2, but that structure showed an inactive conformation," Sun explained. Proteins often have active and inactive forms, regulated by different ...