As such, platforms that look at the function of proteins, so-called “functional proteomics,” are desperately needed for kinase-targeted therapies. The Kinome Core represents a functional proteomic ...

Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit ...

most provide limited kinase assay breadth, and many utilize varying assay formats within the panel, making it difficult to compare results. Figure 1. The human kinome is comprised of 518 protein ...

Stunnenberg, Wei-Wu He, Päivi Ojala, and Jussi Taipale. Application of active and kinase-deficient kinome collection for identification of kinases regulating Hedgehog signaling, Cell 133 ...

Kinomics is the study of the kinome, a global description of kinases and kinase signaling. Since kinases drive numerous signaling pathways in biology (both normal and disease), determining the ...

The kinome refers to hundreds of kinase enzymes that play critical roles in signaling cascades and lead to activation or inhibition of their target proteins, however the roles of many of these kinases ...

The kinome, made up of enzymes called kinases, provides a tremendous opportunity for drug discovery. While more than 30 kinase inhibitors have been approved for the treatment of disease ...

FREMONT, Calif.--(BUSINESS WIRE)-- DiscoveRx announced today the successful expansion of its industry leading KINOMEscan™ kinase assay panel for kinase inhibitor profiling and screening services.

It targets multiple pathways in the tyrosine kinase kinome. We saw early data presented from a trial exclusively in China that enrolled 15 patients. It’s a very small clinical trial, which is ...