Acute limb ischemia occurs due to a sudden decrease in the blood flow to a limb, resulting in a potential threat to the viability of the extremity. Unfortunately, the threat is not only to the ...

Chronic limb-threatening ischemia is known to be caused by peripheral ... it can ultimately lead to necrosis and amputation. Muscle microvasculature responds to hypoxia by dilating in an attempt ...

Persistent over-dilation of muscle microvasculature may be one cause of chronic limb-threatening ischemia, recent studies by Kuopio University Hospital and the University of Eastern Finland show. In ...

Then I began to develop an HGF-based drug to treat patients suffering from types of severe critical limb ischemia that could lead to necrosis in a lower limb, and ultimately amputation ...

[8] The rationale of APSV is based on the observation that in ischemic limbs, blood moves at much slower velocity in the distal leg arteries compared with blood in nonischemic limbs. This is noted ...