A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

The research team discovered that activation of this stress pathway, known as the integrated stress response (ISR), prompts microglia to produce and release toxic lipids. These lipids damage ...

The body's stress response is a powerful and wonderfully integrated series of responses that under normal conditions functions to facilitate fight/flight responses, restore homeostasis, and promote ...

The Lloyd Lab main research focus is the enterovirus infection triggers of integrated stress responses and Type 1 Diabetes. Enteroviruses such as poliovirus and coxsackievirus shut off cap-dependent ...