Glucose in the blood is the major stimulant that regulates the insulin gene expression and enables the beta cells to produce insulin and maintain an adequate store of intracellular insulin to ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Over 500 million people worldwide suffer from diabetes—a disease that contributes to major complications such as stroke, ...

Despite the destruction of pancreatic beta-cells, the researchers found that stimulation of pancreatic ductal cells with GSK126 and tazemetostat could influence insulin (INS) gene expression and ...

Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, ...

The FoxO1 transcription factor, which is influenced by leptin, also directly impacts insulin gene expression; when dysregulated, it further impairs insulin release and signaling, contributing to ...

Tamara Casteels was able to show that reducing the expression of the chromatin protein SMNDC1 leads to the insulin gene being switched on in alpha cells. This effect was observed not only in a ...

suggesting that this regulatory element may be influential in insulin expression, perhaps playing a role in energy homeostasis.