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Nature15y
Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth
Cell Signaling no. 9271), Akt (1 in 500, Cell Signaling no. 9272), p85 (1 in 500, Upstate no. 06-195), IRS-1 (1 in 500, Upstate no. 05-1085), IRS-2 (1 in 500, Upstate no. 06-506), PDGF (1 in 250 ...
Nature18y
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian target of ...
Nature22y
Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway
IRS-1 regulation is selective, as RA did not influence IRS-2 or SHC levels. Downstream signaling events were also selectively reduced, as RA abrogated IGF-I-stimulated AKT activation but did not ...
Nature22y
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation
Two major downstream signaling pathways are associated with IGFRI activation: IRS-1 and Shc binding lead to ... subunit leads to activation of the PI3K-AKT cell survival pathway (Dudek et al., ...
Nature9y
Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways
The insulin receptor signaling pathway is a major mechanism underlying the development of diabetes and MetS. The IRS-1/phosphatidylinositol 3-kinase (PI3K)/Akt axis plays a key role in insulin ...