Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IκB kinase homologs, ...

Phosphorylated IRF3 dimerizes and translocates to the ... metabolic dysfunctions associated with NAFLD. The STING signaling pathway is a pivotal component in the inflammatory and metabolic ...

activate two connected signaling pathways called the TLR3/4 and TBK1-IRF3 pathways. This activation leads to the production of the interleukin-33 (IL-33) protein, which stimulates inflammation in ...

The study found that statins can reduce cancer-causing chronic inflammation by inhibiting the TBK1-IRF3-IL-33 signaling pathway. Lipophilic statins are a safe and efficient preventive option.

activate two connected signaling pathways called the TLR3/4 and TBK1-IRF3 pathways. This activation leads to the production of the interleukin-33 (IL-33) protein, which stimulates inflammation in ...