Team says IL7R mutations in 9% of T-ALL lead to ... the way to the development of new drugs that target IL-7R-mediated signaling in T-ALL. Their initial studies in cultured cells suggested that ...

Figure 6: The emptyhive phenotype is caused by a recessive mutation of Atp11c. Although ATP11C is clearly not essential for all IL-7-dependent ... or branch of IL-7R signaling or the migration ...

Normal controls showed sparse staining for all stains. The scores for each core were averaged ... 22 For CCR7, CXCL12, CXCR4, and IL-7R, a score of < 1 was regarded as negative and ≥ 1 as positive.

October 21, 2011 (Montreal, Quebec) — A mutation in the interleukin-36 receptor antagonist (IL-36Ra) has been identified as a cause of the unregulated secretion of inflammatory cytokines and ...