The therapy has a direct cytotoxic effect on tumor cells that express IL-2 receptors and depletes host Tregs to enhance ...

and high-affinity IL-2 receptors, and they are expressed individually and variably on distinct cell types. PEG modification, IL-2 mutant design, fusion Fc, bispecific antibody design, combination ...

Anti-CD25 mAbs that selectively block IL-2 receptors (IL-2 receptor antagonists) on activated T helper cells are being used prophylactically as complementary immunosuppression with CsA and ...

The FDA has granted a fast track designation to rezpegaldesleukin for treating patients aged 12 years and older with moderate ...