Finally, IGF-1R inhibition attenuated repair by both NHEJ and HR in HEK293 reporter assays. These data indicate that IGF-1R influences DSB repair by both major DSB repair pathways, findings that ...

Also given the role that IGF-1R plays in cancer ... assay kits contain all supplies needed to perform the assay, including cryopreserved reporter cells, optimized media for use in recovering ...

In a collaboration with Dr. Lee Helman and colleagues at the National Cancer Institute the patented Liquid Tissue®-SRM assay technology has been shown to enable for the first time reliable ...

Fabre and Roche began working together on the development of a robust prototype immunohistochemistry assay as a future companion ... determination of IGF-1R expression in patients enrolled in ...

We have observed that chemosurviving (cells that survive acute chemotherapy insult) colon cancer cells are enriched in CSCs and express increased levels of IGF-1R (4.5-fold) (Transl Oncol. 2009;2:321) ...

Results: Src inhibition decreased proliferation of PCa cells, and migration in modified Boyden Chamber and wound assays. In contrast, IGF-1R blockade induced apoptosis (increased Sub-G1 fraction cells ...