However, very little has been done to prove absolutely that the expression or activation of the IGF-1 signaling pathway at physiologically relevant levels is sufficient to cause a healthy prostate ...

“Thus, our results reveal IGF-1 signaling as yet another previously unappreciated pathway affected by verapamil and TXNIP that may contribute to the beneficial verapamil effects in the context of Type ...

IRS-1 is essential to mitogenic type 1 insulin-like growth factor receptor (IGF-IR) signaling. IRS-1 is activated by the EGF receptor, c-Met and the Ewing's sarcoma ongogene. IRS-1 plays a ...

a component of the insulin/IGF-1 signaling pathway. The work suggests that reducing insulin/IGF-1 signaling (IIS), for example, by eating drastically fewer calories, could be one way for humans to ...

Previous studies have revealed that the insulin/insulin-like growth factor 1 (IGF) signaling pathway has an important role in energy metabolism. Other molecular pathways associated with energy ...

Disruption of IGF signaling pathways by neutralizing IGF-I and IGF ... MEDI-573 is in phase 1 clinical evaluation in patients with advanced solid tumors and is planned to begin phase 2 studies ...

A study of animal and human brains uncovered what causes infantile spasms and identified a hormone that could be used to treat and alleviate symptoms. By studying the brains of infantile spasm (IS) ...

Early-life brain injuries reduce IGF-1 levels and impair the IGF-1 signaling pathway "It has been previously reported that IS patients with preexisting brain abnormalities have low levels of IGF-1 ...

“The insulin/IGF signaling pathway is a key pathway in the regulation ... in part to activation of interferon regulatory factor 1 (IRF1).” “Our findings suggest that SARS-CoV-2 infection ...