After determining that the HD gene is located on chromosome 4, the members of the ... with HD have a 50% chance of receiving the mutated HTT gene and thus developing the disease later in life.

Part of the HTT gene contains repeats of the trinucelotide ... In the cases of Huntington’s disease, the specific chromosome involved is chromosome 4. Dominant inheritance means that only ...

Examples of conditions associated with gene mutations on chromosome 4 include neurological and neurodegenerative disorders such as Parkinson's disease, Huntington's disease and narcolepsy.

In a brain organoid model of the disease, the researchers found that mutations in the Huntington gene HTT also affect CHCHD2, which is involved in maintaining the normal function of mitochondria.

There is growing evidence to support the hypothesis that there is a neurodevelopmental component to the late-onset neurodegeneration occurring in the brain of huntingtin gene (HTT gene ...

Huntington’s disease is caused by a mutation in the HTT gene that causes the body to create a rogue version of a protein called huntingtin; this altered protein damages parts of the brain.