The M2 isoform of pyruvate kinase, muscle (PKM2), catalyses the final and also a rate-limiting reaction in the glycolytic pathway. PKM2 is present in few types of proliferating normal cells ...

The latest paper shows how it triggers aerobic glycolysis, processing glucose ... we can block both of those cancer-promoting pathways. PKM2 could be an Achilles' heel for cancer." ...

suggesting that by keeping PKM2 activity low, cancer cells channel incoming glucose to metabolic pathways that generate antioxidants, and thereby survive oxidative stress." Glycolysis is a multi ...

When immune cells called neutrophils release pyruvate kinase M2 (PKM2), an enzyme that acts in the last step of the glycolysis pathway, PKM2 aids wound healing by promoting the development of new ...

Creative Proteomics announced the launch of a Glycolysis Pathway Analysis platform that incorporates LC ... validate mechanism-of-action for drugs targeting metabolic enzymes like PKM2 and LDHA." The ...

The research further explored the interaction between PAK5 and PKM2, an enzyme integral to glycolytic activity. PKM2's elevated levels in cancer cells are well-documented, but its post ...

A cancer-promoting protein's pathway into the cell nucleus ... growth The researchers also found that the two glycolysis genes activated by PKM2, called GLUT1 and LDHA, are required for glucose ...

Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...

PD-1 blockade with camrelizumab after chemoradiotherapy in nasopharyngeal carcinoma. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A Global Summit for Oncology Innovators. This abstract ...

The latest paper shows how it triggers aerobic glycolysis, processing glucose ... we can block both of those cancer-promoting pathways. PKM2 could be an Achilles' heel for cancer." ...