Glycogen phosphorylase (GP) is a pivotal enzyme responsible for the catabolism of glycogen into glucose, a process intricately linked to blood glucose regulation. In the context of type 2 diabetes ...

INV-101 is a first-in-class oral small molecule that selectively inhibits glycogen phosphorylase, disrupting the metabolic reprogramming of pro-inflammatory immune cells. This novel mechanism ...

In this pathway, PKA phosphorylates the enzyme phosphorylase kinase which in turn phosphorylates, and activates glycogen phosphorylase. The latter is the enzyme involved in the initial and rate ...

“We demonstrate that the decreased abundance of malin, an E3 ubiquitin ligase, impaired nuclear glycogenolysis by preventing the nuclear translocation of glycogen phosphorylase and causing ...

McArdle's disease is a genetic disorder due to mutations of the PYGM (myophosphorylase or glycogen phosphorylase) gene, which has an autosomal recessive inheritance. Due to the rarity of the ...

Nevertheless, the glycogen phosphorylase, an enzyme that converts glycogen to glucose when energy is needed, was significantly lower. "As a result, while muscle continued to make glycogen ...