Their findings, published in Nature Communications, reveal an oxidation-independent adhesion process driven by interactions between EGF/EGF-like domains and GlcNAc-based biopolymers. Marine ...

More information: Sara Formichetti et al, Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo, PLOS Genetics (2025). DOI: 10.1371/journal.pgen.1011507 ...

The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.