Additional experiments suggested that the lectin domain of normal GnT-IVa and GnT-IVb had little to do with the actual formation of the β1-4-GlcNAc branch on substrate glycoproteins. The team ...
More information: Sara Formichetti et al, Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo, PLOS Genetics (2025). DOI: 10.1371/journal.pgen.1011507 ...
The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.
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