A simplified signaling pathway is depicted to highlight known examples of bona fide oncogenes that are subjected to dysregulation by various mechanisms. It is clear that a signaling pathway can be ...

The assembly or disassembly of protein complexes takes place in spatiotemporal manner within the cell, leading to switching the signaling pathways on or off. (B) Illustrates a specific example.

(A) Recapitulation of well documented cell communication pathway for Macrophage recruitment under the Parabiosis condition. Ccr2 recognizes Ccl2, which initiates a signaling cascade to activate ...

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone ...

Inhibiting bone resorption via an effect on the RANK/RANKL/OPG signaling pathway (see following section); Enhancing bone formation by prolonging the lifespan of osteoblast cells (Figure 1A).