Toxicity did not differ significantly among genotypes. GSTP1 codon 105 polymorphism may be predictive for the response to irinotecan-based chemotherapy in patients with MCRC, with the Val-allele ...

The GSTP1 genotype seemed to have the strongest ... to detoxify environmental chemicals by GST enzymes due to functional polymorphisms may contribute to differences in PCa prevalence and incidence.

The authors found that the GSTP1 polymorphism was associated with increased survival in these patients, but that the GSTM1 and GSTT1 polymorphisms had no effect on patient survival. These findings ...

Thymidylate synthase and thymidine phosphorylase expression in resected colorectal liver metastases do not predict overall survival nor response to chemotherapy This is an ASCO Meeting Abstract from ...

However, 3 polymorphisms in GSTP1, GSTT1, and GSTM1 genes decrease GST enzyme activity. It has been hypothesized that the presence of these polymorphisms may influence cancer patients survival. The ...

In a preclinical study, THIO and its new described dimer form were found to be potent inhibitors of Glutathione S-transferase Pi (GSTP1), a key enzyme implicated in cancer progression and ...

CHICAGO, March 20, 2025--(BUSINESS WIRE)--MAIA Biotechnology, Inc., (NYSE American: MAIA) ("MAIA", the "Company"), a clinical-stage biopharmaceutical company ...