In ischemic, toxic and obstructive models of AKI, we demonstrate a causal association between epithelial cell cycle G2/M arrest and a fibrotic outcome. G2/M-arrested proximal tubular cells ...

As a result, cells remain arrested in G2 and can not enter the M phase of the cell cycle. ATM/ATR, ataxia-telangiectasia mutated/ataxia-telangiectasia and Rad3 related. , the G2 checkpoint is ...

This protein is involved in cell cycle arrest and transcription of proteins ... It is organised into 4 distinct phases; G1 phase, S phase, G2 phase and M phase, and controlled by the presence ...