Figure 1: The immunosuppressive compound rapamycin bound to FKBP12 and the FRB domain of mTOR. Why has a pathway with such florid molecular diversity emerged not once but twice? Only a few of the ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...