IL-6 and downstream JAK-dependent signaling pathways have critical roles in the ... 11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin ...

The article details how FGFR3 signaling suppresses critical pathways such as Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP), and how its activation elevates cell cycle ...

The activation of FGFR3–MAPK–STAT signaling pathway has been found to inhibit chondrocyte proliferation and extracellular matrix synthesis in the growth plate, leading to reduced endochondral ...

The article details how FGFR3 signaling suppresses critical pathways such as Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP), and how its activation elevates cell cycle ...

Deregulation of FGFR3 signaling is implicated in the pathogenesis ... a hormone antagonist that blocks multiple steps in the androgen receptor–signaling pathway. It is used in adult and ...