but may remain undetectable because the resulting receptor protein is so active that development may be compromised at an early embryonic stage. Alternatively, the gene structure of FGFR3 may ...

Additional in vivo and in vitro analysis indicated that the antibody was active against normal FGFR3 and mutated forms of the protein that are associated with cancer. The authors therefore suggest ...

To prevent excessive intracellular signaling and rescue the symptoms of achondroplasia, we have developed a recombinant protein therapeutic approach using a soluble form of human FGFR3 (sFGFR3 ...

The authors decided to use immunohistochemistry to evaluate FGFR3 protein expression in 116 tissue samples from patients with NSCLC and then use Sanger sequencing to probe the mutation status of ...

Antibody Targeting The Protein FGFR3 Inhibits Cancer Cell Growth Date: April 28, 2009 Source: Journal of Clinical Investigation Summary: Several forms of cancer are associated with either ...