This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound ...
"When we originally tried to target this exon with older techniques, it didn't work," said graduate student Shraddha Shirguppe, also a co-first author of the study. "Combining the newer base ...