In this study, we explored the effects of Akt and ERK pathways on EGFR-mediated signaling and motility in human prostate cancer cells. Our novel findings suggest that EGF-triggered ERK activation ...

Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the ...

Effect of NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, on radiosensitivity of oral cancer cell line through G2/M phase checkpoint regulation. This is an ASCO ...

The canonical pathway of mTOR activation depends on mitogen-driven signaling through PI3K/AKT, although alternative non-AKT dependent activation through the Ras/MEK/ERK pathway is now recognized. 4 ...

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the Ras–MEK–ERK pathway (Panel C) are inhibited. In contrast, other signaling events, such as the activation of the p38 ...