ErbB2 kinase activity promotes Ras-mediated stimulation of downstream protein kinase cascades, including the Ras/Raf-1/MAPK/ERK kinase (Mek)/extracellular signal-regulated kinase (Erk) pathway ...

Aggressive breast cancer can become unresponsive to monoclonal antibody treatment, but targeting tumor-resident bacteria may extend its effectiveness.

(Scientists also use the name ERBB2 to describe this surface receptor ... even when the HER2 signaling pathway was activated. PTPD2, therefore, is what scientists call a "positive regulator ...

Together, ERBB2 and NRG1 convey a growth signal and ... AKT and GSK3β/β-catenin signaling pathways,” wrote the authors of the Nature Cell Biology article. “Transient induction of caERBB2 ...

Further, it was found that the ERBB2 signaling pathway was significantly enriched in almost all RTKs, while the type I interferon was enriched in all except three RTKs, indicating that RTKs share ...

Envision this possible future clinical scenario: a breast cancer patient and her physicians are deciding on the best possible ...

Cellular signaling pathways control the proliferation, differentiation, survival, and migration of normal cells. But, dysregulation of these cells can cause tumors to form and grow. The ...

report that neuregulin-1 signaling involving the erbB2 receptor pathway-possibly in concert with Notch signaling-is critical for cellular differentiation that allows appropriate cortical development.

Novocell Inc. has announced research findings that for the first time identify two prominent cancer cell signaling pathways as essential ... with insulin-like growth factor-1 (IGF-1R), and ERBB2/3.

As shown on the right, in tumor cells, ligand-independent activation of the ERBB signaling cascade can occur through multiple mechanisms including, for example, gene amplification of ERBB2 (in ...

The pathway, they discovered ... "A novel phosphatidic acid-protein tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cell" appeared online April 10, 2015 ...