In a systematic review and meta-analysis of trials of non-vitamin K oral anticoagulants vs. single antiplatelet therapy, ...

Purpose The pharmacology, pharmacokinetics, efficacy, and safety of apixaban are reviewed ... and has been administered in a twice-daily dosing regimen in clinical trials without the need for ...

This raises a question if dose reduction ... of either apixaban or rivaroxaban for extended management of blood clots, noting this was a "weak recommendation" with "very low certainty evidence." ...