Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the ...

The Ras/Raf/MEK/ERK signaling pathway consist of a kinase cascade ... of signal transduction inhibitors are also shown in this diagram. The membrane localization of these components is often ...

Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

a compound that inhibits DUSP6 to sustain ERK pathway activation. Findings suggest that BCI modulates the duration of ketamine's synaptic and behavioral effects, potentially reducing the need for ...

The low response rate—20%—is comparable to response rates observed in other treatments, such drugs that target MEK enzymes in the MAPK/ERK pathway. Because of that low response rate ...

We and others previously demonstrated that inhibition of the KRAS-RAF-MEK-ERK pathway enhanced autophagic flux and dependency in several PDAC models. Furthermore, we demonstrated that concurrent ...

“JSI-1187 is a selective ERK1/2 inhibitor. By utilizing an ERK inhibitor against tumors harboring mutations in the MAPK pathway, we hope to develop more effective single-agent and combination ...

Signaling through the MAPK/ERK pathway is activated through a variety of external stimuli, dependent on the G protein subtype coupled to the GPCR. Detecting ERK1/2 phosphorylation mediated by ...

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...