A new article argues dystrophin immunogenicity is an under-examined issue in the treatment of Duchenne muscular dystrophy.

"To understand the mechanism, it is important to know that in DMD, various mutations in the dystrophin gene prevent the production of a functional gene product, i.e. a protein. Rather, the ...

One gene, for instance, controls the production of dystrophin, a protein that protects muscle fibers from damage. A change in this gene results in limited or discontinued dystrophin production.

Dystrophin is part of a protein complex linking the cytoskeleton of muscle fibers to the surrounding connective tissue (basal lamina). It’s a long protein with numerous redundant coils (purple balls), ...

Unlike traditional approaches that aim to replace or repair the missing dystrophin protein, K884 focuses on bolstering the natural repair mechanisms of muscle stem cells. This strategy not only ...

Duchenne muscular dystrophy is a condition that primarily affects young boys, starving their bodies of dystrophin protein required for muscle function. The Food and Drug Administration has said ...

Today, based on the wealth of knowledge about the underlying genetic and molecular mechanisms of DMD ... cell-based therapies (e.g., replacing dystrophin-deficient muscle cells with stem cells ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

"The EC's indication that European Union member states have a mechanism to maintain treatment ... caused by the lack of functional dystrophin protein. Dystrophin is critical to the structural ...

Duchenne muscular dystrophy is a condition that primarily affects young boys, starving their bodies of dystrophin protein required for muscle function. The Food and Drug Administration has said ...