STAT4 is not classically considered as a factor involved in the type 1 IFN pathway. Conversely, it has a critical role in cellular growth and T-helper 1 differentiation, with interleukin 12 ...

Moreover, AHR, non-eosinophilic inflammation, and IFN-γ expression were impaired in allergen-challenged IL-12Rβ2- and STAT4-deficient ... the IL-13Rα2-mediated pathway is also an important ...