Thus, Tet3 serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation. You have full access to this article ...

Researchers have identified the epigenetic proteins Tet2 and Tet3 as key regulators of B ... the reversible addition (methylation) or removal (demethylation) of chemical bonds, so-called methyl ...

The role of TET enzymes in DNA demethylation Active DNA demethylation begins with the oxidation of 5mC by TET enzymes (TET1, TET2, and TET3) that convert 5mC to 5hmC.

The researchers suspect the fear stimulus is so strong that it activates other demethylation proteins -- possibly Tet2 or Tet3 -- that can compensate for the lack of Tet1. During the memory ...

They further noted in their report, “The three mammalian members of the TET family (TET1, TET2, and TET3) catalyze the ... changes and health threats. DNA demethylation helps our immune cells ...

Levels of the surface receptor GluR1, orange, are shown in unmodified neurons, left, and in those with increased levels of Tet3, right. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

Histone H3K27 methylation status is regulated by the addition of methyl (Me) groups by the enzyme EZH2 and demethylation by UTX and JMJD3 histone demethylases (Panel A). Lochmann et al.

By combining analysis of patient samples with CRISPR-DiR technology, we found that demethylation and up-regulation of an oncogene after treatment with a hypomethylating agent can indeed occur and ...

The team found that fasting switches on a process whereby two proteins, TET3 and HNF4a, build up in the liver and elevate the production of blood glucose. In a healthy person, this process is ...