DNA repair and genome surveillance mechanisms, along with their integration with cell cycle progression and myriad other processes such as transcription and metabolism. The modulation of DNA ...

For both DNA polymerase ε and δ, PCNA is a cofactor and acts as a DNA clamp, which is significant in DNA synthesis as well as DNA repair. At the end of the termination phase, a phosphodiester ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized ...

This vicious cycle could explain EdU’s mysterious toxicity to cells. It traps them in a loop of constant DNA repair that can never “fix” the problem, until ultimately the cell triggers a ...

It is essential for the biological system to have a mechanism in place to detect and repair these errors. The cell cycle of eukaryote cells includes four main phases for the replication of DNA and ...

Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome. A gene that ...

Zooming in on individual cells The body has various mechanisms to repair DNA, but the process can differ from cell to cell. This makes it important to study DNA repair in individual cells.

A study in Oncogene shows that PPP2R1A mutations increase sensitivity to ATR inhibitors in ARID1A-mutant ovarian clear cell ...

This sequential expression followed the phases of the traditional cell cycle: G0/G1 (the cell grows larger), S (the cell replicates its DNA), and G2/M (the cell prepares for division and then splits).

an organism grows an organism becomes damaged and needs to produce new cells for repair ... cell. When looking at cells with a microscope, the length of different stages of the cell cycle can ...

Circular DNA, thought to be an accidental byproduct, is borrowing the cell’s DNA repair mechanisms to copy itself DURHAM, N.C. -- Like its viral cousins, a somewhat parasitic DNA sequence called a ...

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA. Published online May 16 in the journal Cell, the report describes the ...