Here, we demonstrate that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc ...

These cells express high levels of Axin2, which indicates activity of the WNT signaling pathway. Nabhan et al. 1 suggest that a very local source of the WNT ligand is PDGFRA-positive fibroblasts ...

The researchers started their quest by looking at WNT signaling, a communication pathway used by cells to promote tissue regeneration and wound healing. WNT signaling helps maintain the blood ...

Predictive value of baseline CD66e/CEA serum levels on efficacy of bevacizumab-based treatment in advanced colorectal cancer. This is an ASCO Meeting Abstract from the 2013 Gastrointestinal Cancers ...

“Choosing wisely” in oncology: The example of surveillance positron emission tomography-computed tomography (PET-CT) for patients with colorectal cancer (CRC) treated with curative intent. This is an ...

The Wingless (Wnt) signaling pathway is one of the key regulators of OL development and myelin regeneration. In certain diseased conditions and brain injury, its levels are elevated in the white ...