complement receptor of the immunoglobulin superfamily (CRIg; also known as Z39Ig), as the receptor that is required for this efficient phagocytosis of C3-opsonized pathogens by Kupffer cells.

In conclusion, CRIg, a novel Ig-superfamily complement receptor, binds primarily to the β-chain of C3b and C3c in a location that is distinct from the putative binding sites of other complement ...