This poster introduces the background of Ubiquitins, applications of Ubiquitins in research, and featured active Ubiquitins ...
Alfa Chemistry’s library includes many different PROTAC scaffolds needed to make these advanced bi-functional molecules. These include E3 ligase ligands such as CRBN and VHL, and linkers which act as ...
Whereas the PROTAC approach to target protein degradation greatly benefits ... TPD is currently limited to the few for which ligands have been reported, mostly CRBN and VHL. Identifying druggable E3 ...