Gervais et al. suggest that caspase cleavage of amyloid precursor protein (APP) may initiate a feedback loop that produces β-amyloid deposits in Alzheimer's disease. Figure 1: A model for the ...

A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the ...

A leading hypothesis is that these events are mediated by neurotoxicity of amyloid ... protein precursor (APP) that is the main constituent of senile plaques. Figure 1: APP interaction with and ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

Increasing focus is now being placed on the production of Aβ – a process called proteolysis, during which a precursor protein called amyloid precursor protein (APP) is trimmed by an enzyme ...

but flexible.C99 is the 99 residue transmembrane C-terminal domain of the amyloid precursor protein (APP). C99 is the product of beta-secretase cleavage of C99 and itself serves as the substrate ...

Upon proteolytic cleavage of APP (see insert), Aβ ... Aβ: Amyloid-β; AICD: Amyloid-β precursor protein intracellular domain; APP: Amyloid-β precursor protein; Fpn: Ferroportin; IDE: Insulin ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. For several decades, researchers studying Alzheimer's disease have been working to ...