Chronic limb-threatening ischemia is known to be caused by peripheral ... "Microvascular over-dilation causes hypoxia and cell shrinkage even in healthy muscle," Korpisalo notes.

Persistent over-dilation of muscle microvasculature may be one cause of chronic limb-threatening ischemia, recent studies by Kuopio University Hospital and the University of Eastern Finland show. In ...

A group of 54 patients with acute or chronic limb ischaemia were initially treated with low dose intra-arterial thrombolytic therapy using streptokinase (10,000 units h-1) or plasminogen activator ...

In recent years data have accumulated showing that nitrite protects against IR injury in the heart, brain, kidney and liver, as well as in chronic limb ischemia (for review see refs. 1 ...