p-Akt/p-S6) was found to be commonly expanded in the two leukemia samples collected at relapse. Importantly, the presence of cell subpopulations expressing this same signaling profile at diagnosis ...

2 The EGF signaling pathway regulates cell growth, proliferation, differentiation, and survival through the activation of EGFR and downstream cascades like RAS/RAF/MEK/ERK and PI3K/AKT.

It regulates cell profliferation and survival ... Cells with Skp2 produced more Glut1 when induced by epidermal growth factor signaling. Akt activates Glut1. • Reduced Akt activation, Glut1 ...

Multiregion whole exome seuquencing of pre- and early neoplastic lung lesions. A new diagnostic method based on RT-PCR and CLART technology for non-small cell lung cancer (NSCLC) to detect major ...

Briefly, copy number loss performance was assessed using tumor- or normal-matched cancer cell lines as true positive and true ... primed to best respond to co-targeting of PTEN-PI3K-AKT and AR ...