Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). The phosphorylation of EZH2 at Thr 487 disrupted EZH2 binding with the other ...

They discovered that the sarbecovirus lineage nucleocapsid protein harbors a typical GID as well as a CDK1 phosphorylation site with a conserved pSPxK/R that could help phosphorylation of GSK-3.

And that phosphorylation has to occur at a specific ... The team showed only those cells with EZH2 phosphorylated by CDK1 differentiated into bone cells. Genes crucial to bone formation were ...

The checkpoint kinase WEE1 catalyzes the inhibition of cell cycle progression and CDK1 phosphorylation. WEE1 inhibitors have demonstrated clinical benefits in gynecological malignancies, yet limited ...

FMNL2 is notable as it has been previously implicated in actin filament assembly. CDK1 phosphorylation of FMNL2 increases the adhesion area, its dephosphorylation in the G2 phase was implicated in ...

Extreme normality in superficial or seemingly inconsequential matters can be a sign that something is deeply wrong. This thought may have occurred to scientists at the University of Colorado (CU ...

Motif analyses in this subset of genes revealed binding sites for FOXM1, a master transcriptional regulator of mitotic genes, and a target for CDK1 phosphorylation. Acting on a circuit, FOXM1 ...

They discovered that a specific change (phosphorylation ... The study suggests that targeting another protein (CDK1) can disrupt the Top1-mediated DNA damage-associated repair process, potentially ...