We have shown that the cyclin E–Cdk2 complex is recruited to origins of DNA replication by the origin-recognition complex (ORC) and Cdc6 ... by MCM action or downstream events, but before ...

The inhibition of pre-RC assembly is dependent on a functional retinoblastoma (RB) protein, which mediates downstream ... cyclins, CDK2 inhibition resulted in the attenuation of cdc6 and cdt1 ...

has superior selectivity compared to clinical-stage CDK2 inhibitors and induced robust downstream CDK2 pathway suppression. When combined with current standard of care therapies, MRT-9643 drove ...