As FasL is known to play a major role in the ... CA). Fas-L (C-178), FAS (B-10), caspase-3 and β-actin antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).

In a cell-free system, caspase-2, -7, -8 and -9, but not caspase-3 and -10, cleaved SMS1 ... and likely represent proximal events in Fas signaling. FasL-induced ceramide production and cell ...

Furthermore, Akt activation is known to protect cells against apoptosis agents belonging to the TNF family of death ligands, such as Fas ligand (FasL) which acts through ... Fas induced activation of ...

In support of this, cells carrying mutations in FasL, or its receptor Fas, were much less likely to undergo apoptosis when challenged with Aβ25-35. In addition, the researchers were able to show that ...