and mediators of organ-specific or tissue-specific control systems (Fig. 6). Our understanding of the underlying mechanisms of cachexia in individual patients is crude at best; accordingly ...

Yet none of the inflammatory mediators known to induce cachexia in cancer seemed to play an important role during infection. "This came as quite a surprise to us," says first-author of the study ...

we provide a concise review of the major thematic areas driving current cachexia treatment strategies. These include pharmacologic agents targeting signal mediators within CNS controls of ...

Mouse model experiments also revealed that adipose-specific G-protein-coupled receptor 81 (GPR81) is a key mediator of the catabolic effects of lactate. Cachexia is a complicated metabolic ...

With cachexia, the muscles in your body will waste away regardless of how much you eat. The condition causes severe weight loss. (Photo Credit: Dr P. Marazzi/Science Source) Cachexia (aka ...

Called cachexia, it’s an under-recognized syndrome that researchers are still trying to tease out, and one that’s attracting more interest from drugmakers. On Saturday, Pfizer reported that an ...

Cachexia causes extreme weight loss and muscle wasting. It is a symptom of various chronic conditions such as cancer, chronic renal failure, HIV, and multiple sclerosis. Cachexia predominantly ...

Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer ...

Rheumatoid arthritis (RA) can lead to a metabolic state called rheumatoid cachexia, or muscle wasting. This form of cachexia happens when your body loses muscle mass and keeps fat mass.

This is the battle of cancer cachexia. The mind and body become entangled in a relentless downward spiral in this grim, hidden struggle. Each affects the other in inescapable ways, creating a ...

Patients with cancer cachexia assigned ponsegromab gained significantly more weight than those assigned placebo. Researchers observed improved appetite and higher physical activity in the ...