Researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have described the molecular mechanisms of cachexia during viral infection and identify a surprising ...

Figure 2: Severe muscle depletion can occur in patients with cachexia and/or obesity. Here, we outline the key mechanisms in cancer-associated cachexia, relying on animal data and pointing out ...

Cachexia is clinically obvious in its advanced phase (with gross loss of fat and skeletal muscle), and as such has been recognized as an adverse effect of cancer since the time of Hippocrates.

1 The growing understanding of the mechanisms underpinning cachexia has prompted an increasing number of studies, now in phase 1 or phase 2, that use highly specific, potent therapies targeted at ...

Now, researchers have identified a mechanism by which viral infection can lead to cachexia. In mice infected by a particular virus, killer T cells trigger the wasting of fat tissue and body weight, ...

Cachexia is a condition which denotes the excessive loss of weight. It occurs because of the depletion of adipose tissue and muscle mass in people who are not trying to lose weight. It is also ...

It is now clear that a key mechanism underlying cachexia is the increased breakdown of muscle protein, along with dampened protein synthesis, which leads to overall muscle loss. Studies in 2001 ...

The CNS is integral in the pathogenesis of cancer cachexia through varied mechanisms including hypothalamic and neuroendocrine alterations that promote and accelerate anorexia and peripheral tissue ...

41 Sarcopenia and cachexia are frequent comorbidities in chronically ill patients, they aggravate the underlying disease and negatively influence the clinical outcome. As such, more research is needed ...

In all doses, they gained weight. "These results provide strong evidence that we have unlocked a mechanism to interrupt a critical driver of cachexia," Charlotte Allerton, head of Discovery and ...

The higher risk of cachexia may also be related to environmental or pathophysiological mechanisms outside of those explored in the study, they added. “As the field of cancer cachexia sees ...