Despite the fact that HIV is a multifactorial disease, research has shown that specific targetingof CXCR4 and CCR5 is a potential therapeutic tactic for HIV as well as other immune situations like ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge ...

The AIDS virus binds to several different cell receptors and at least one or two different co-receptors, called CXCR4 and CCR5, to enter and infect cells. The use of CCR5, CXCR4 or both co ...

When HIV selectively attaches to a particular coreceptor on the surface of a host CD4 cell. HIV can attach to either the CCR5 coreceptor (R5-tropic) or the CXCR4 coreceptor (X4-tropic) or both ...

HIV infects cells by first binding to the CD4 receptor and then one of two coreceptors, the chemokine receptors CCR5 and CXCR4. Usually, these receptors are the targets for substances that activate ...

which indicates the probability of classifying a CCR5-tropic (R5-tropic) virus falsely as CXCR4-tropic (X4-tropic). On the basis of the false positive rate (FPR), viruses are categorized as X4 ...

Most people with HIV start out with a virus that uses a receptor called CCR5. "Over time their virus population may switch to using CXCR4, for reasons we still don't fully understand. Several ...

Experiments using cells that expresses both CXCR4 and CCR5, such as human peripheral blood mononuclear cells, rarely result in the selection of drug-resistant viruses that change coreceptor usage.