65 Effects of CXCL12/CXCR4 on cancer and its mechanism CXCL12 affects cancer biology mainly via the following two mechanisms: (a) by direct autocrine effects that promote cancer cell growth ...

The current study evaluates the molecular mechanisms of CXCL12 and CXCR4 in prostate cancer cell migration and invasion. We report that functional CXCR4 is significantly expressed by prostate ...

and its interpretation has been identified in 23 kinds of cancer. CXCR4 overexpression in tumor cells promotes tumor growth, invasion, angiogenesis, metastasis, recurrence, and resistance.

Immune escape correlates with an inflamed phenotype in malignant mesothelioma. Prophylactic cranial irradiation (PCI) and consolidation thoracic radiotherapy (TRT) for extensive stage small cell lung ...

The novel mechanism of CXCR4 inhibition increases the ability of T-Cells to track and destroy cancer. “CXCR4 inhibition is a novel approach to immunotherapy whose potential we are only beginning ...

Lung cancer patients whose tumors over-express a cell surface molecule called CXCR4 do significantly worse than those who do not, Canadian researchers have found. Their work, reported at the 2nd ...

Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and ...

WHIM syndrome (characterized by warts, hypogammaglobulinemia, infections, and myelokathexis) is a rare immunodeficiency caused by inherited autosomal-dominant mutations in CXCR4 that confer gain ...

Schwab describes it as "a particularly devastating cancer" due to the absence ... They did this by blocking CXCR4--a receptor protein that targets T cells--helping T cells to mature and attract ...

A protein called PCSK9 determines how pancreatic cancer cells metastasize to different parts of the body.

But they are the inspiration for a new approach to treating cancer that uses engineered fat cells to deprive tumors of nutrition. Researchers at UC San Francisco used the gene editing technology ...