The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

A newly identified function of C-X-C motif chemokine receptor 2 (CXCR2) is promoting monocyte ... and C-X-C motif chemokine receptor 4 (CXCR4) in the plasma or atria in patients with AF has ...

Now, Bernhagen and colleagues, writing in Nature Medicine, have identified MIF as a ligand for the CXC-chemokine receptors CXCR2 and CXCR4, and suggest that targeting MIF could be used as an ...