The replication fork is assembled as a complex of numerous proteins, one of which is an 11-subunit collective called CMG that unwinds and separates the DNA into two individual strands. The ...

DNA replication is an essential part of cell division ... The team directly tested the ability of a helicase called CMG to unwind structures and determined that it was able to bypass G4s and ...

"The replication process is carried out ... unexpected discovery about how the CMG helicase manages to travel along DNA ...

but also acts as a brake for DNA replication, preventing an essential replication enzyme called CMG helicase from functioning. To start synthesizing DNA, the cell's enzymes must first break down CDT1.

but also acts as a brake for DNA replication, preventing an essential replication enzyme called CMG helicase from functioning. To start synthesizing DNA, the cell's enzymes must first break down CDT1.

Their next aim was to determine exactly how the structures halt DNA replication. The two major possibilities were that the helicase was arrested or that the polymerase was inhibited. The team directly ...